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Rutile titanium dioxide, the most common form of TiO2, possesses a tetragonal crystal structure and exhibits unique physical and chemical properties that make it suitable for a wide range of applications. One of the key advantages of rutile TiO2 is its high refractive index, which ranges from 2.4 to 2.7. This high refractive index enables rutile TiO2 to provide excellent hiding power and whiteness in coatings, plastics, and other materials.

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The vitaminC@P25TiO2NPs, on the other side, did not have any effect on cell protection against ROS. This might be due to the fact that vitamin C, a well-known scavenger of ROS, could behave as prooxidant and even promote ROS and lipid peroxidation [39]. It was recently described that at small concentrations of vitamin C, the prooxidant effects dominate; while in large concentrations the antioxidant ones predominate [40]. The effect also depends on the cell state and the interaction of vitamin C with light. In this case, ascorbic acid may act as an antenna to harvest visible light when conjugated to P25TiO2NPs. Indeed, it was previously found that this combination (in some ratios) could have an improved photocatalytic activity, possibly due to a red shift in its light absorbance [41]. Further studies on vitaminC@P25TiO2NPs were not conducted, because of the poor antioxidant capacity [42].

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